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If your children will want to listen to the same music, or watch a video together, an inexpensive headphone splitter lets you plug two headsets into the same device.
Hang a few carabiner clips off of the outside of your carry-on bag. They always seem to come in handy for attaching last minute items.
Whether you are out and about or in your hotel room, you'll want to have a few plastic bags so that you can individually wrap and throw away dirty diapers (there's no diaper genie in the hotel room!). I find these rolled sacks easiest and most space efficient to carry.
These disposable ear plugs help relieve ear and sinus pain and are fitted for a child-sized ear.
These baby wipes come in a soft plastic case, but have a flip-top lid, making them a great choice for travel.
A stuffy nose can make it difficult for baby to nurse and make the effects of air pressure on a baby's ears worse. A few drops of saline solution or breastmilk in her nose often helps our kids. (I have also read claims that saline can help reduce the risk of getting sick on a flight, but I'm not a medical professional). We've used this pre-made saline solution, or you can bring along your own small plastic feeding syringe and saline. Be gentle, even three or four drops can work wonders.
This Car Charger lets you charge up to two USB devices using your car's cigarette lighter. Since most phones, DVD players and iPads / iPods come with a USB charger, this is a great way to charge your devices when you're on the go.